Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism
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چکیده
منابع مشابه
Autophagy in cellular metabolism and cancer
The biology of autophagy Autophagy, or cellular “self-eating,” is a vesicular trafficking pathway that targets intracellular substrates, from entire organelles to protein aggregates and specific proteins, for lysosomal degradation and recycling (1). Identified by genetic and morphologic studies in yeast and mammalian cells, this pathway is now known to be conserved across most of eukaryotic lif...
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Laboratory data have demonstrated that cadmium (Cd) may induce neuronal apoptosis. However, little is known about the role of autophagy in neurons. In this study, cell viability decreased in a dose- and time-dependent manner after treatment with Cd in PC-12 cells. As cells were exposed to Cd, the levels of LC3-II proteins became elevated, specific punctate distribution of endogenous LC3-II incr...
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conclusions these results indicated a potential explanation for reactivation of hbv infection when patients with hepatitis receive rapamycin. results in hepg2.2.15 cells, hbv dna and hbsag increased when host cells were treated with rapamycin and the effect was reversed by autophagy inhibitor, 3-methyladenine (3-ma). materials and methods hepg2.2.15 cells were treated with rapamycin to induce a...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2017
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.14064